期刊
ORGANIC LETTERS
卷 11, 期 22, 页码 5166-5169出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol902066e
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资金
- Natural Sciences and Engineering Research Council of Canada (RJA)
- Stem Cell Network (TJK)
- Michael Smith Foundation for Health Research Senior Scholar award
The new sesterterpenoids alotaketals A (1) and B (2) have been isolated from extracts of the marine sponge Hamigera sp. collected in Papua New Guinea. Their chemical structures were elucidated by analysis of spectroscopic data. Alotaketals A and B have the unprecedented alotane carbon skeleton, and they activate the cAMP cell signaling pathway with EC50's of 18 and 240 nM, respectively.
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