期刊
ORGANIC LETTERS
卷 10, 期 20, 页码 4625-4628出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol801897m
关键词
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资金
- Eby Nell McElrath Postdoctoral Fellowship
- Welch Foundation [E-1571]
- NIGMS [R01GM077635]
- Sloan Foundation
- Camille and Henry Dreyfus Foundation
Direct transition-metal-free, base-mediated intramolecular arylation of phenols with aryl halides has been developed. In the presence of 2.5 equiv of t-BuOK in dioxane at 140 degrees C, the intramolecular cyclization of 3-(2-halobenzyloxy)phenols affords 6H-benzo[c]chromenes in high yields. This reaction proceeds by an initial formation of a benzyne intermediate followed by an aromatic sp(2) C-H functionalization (a formal C-H activation) to form the carbon-carbon bond.
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