期刊
ORGANIC LETTERS
卷 10, 期 5, 页码 837-840出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol702769n
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资金
- NCI NIH HHS [2P30CA23168] Funding Source: Medline
- NEI NIH HHS [EY018481] Funding Source: Medline
Glutathione is a crucial component of the redox homeostasis of cells, and altered levels have been linked to human pathologies. We constructed a latent fluorophore (RhoSS) that responds to cellular thiols in vitro and in cyto following intracellular reduction by glutathione to yield rhodamine 110. Importantly, RhoSS was demonstrated to respond to changing levels of glutathione in cells. This compound represents a class of rationally designed latent fluorophores with exciting potential for monitoring cellular thiols.
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