期刊
ORGANIC LETTERS
卷 10, 期 22, 页码 5293-5296出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol8021897
关键词
-
资金
- National Institutes of Health [GM-49076]
This paper introduces polar and hydrophobic variants of the unnatural amino acid Hao, which mimics the hydrogen-bonding functionality of one edge of a beta-strand. In these variants, the methyl side chain of Hao is replaced with acidic, basic, and hydrophobic groups. These modifications can impart improved solubility and additional side-chain interactions to peptides containing Hao.
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