4.8 Article

In Situ Click Assembly of Small Molecule Matrix Metalloprotease Inhibitors Containing Zinc-Chelating Groups

期刊

ORGANIC LETTERS
卷 10, 期 24, 页码 5529-5531

出版社

AMER CHEMICAL SOC
DOI: 10.1021/ol802286g

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  1. Ministry of Education [R143-000-280-112]
  2. Agency for Science, Technology, and Research (A*Star) of Singapore [R-154-000-274-3051]

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A panel of small molecule-based MMP inhibitors containing rhodanine warheads was assembled using one-pot click chemistry. Upon biological screening, moderate inhibitors were identified which specifically targets MMP-7 and MMP-13 over other MMPs.

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