期刊
ORGANIC LETTERS
卷 10, 期 6, 页码 1231-1234出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol800086s
关键词
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资金
- NIGMS NIH HHS [GM080442, R01 GM080442-01A1, R01 GM080442] Funding Source: Medline
An enantioselective synthesis of indolizidines bearing quaternary substituted stereocenters by way of a rhodium-catalyzed [2 + 2 + 2] cycloaddition of substituted alkenyl isocyanates and terminal alkynes is described. The reaction provides lactam products using aliphatic alkynes, whereas aryl alkynes give rise to vinylogous amide products. Through modification of the phosphoramidite ligand, high levels of enantioselectivity, regioselectivity, and product selectivity are obtained for both products.
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