期刊
ORGANIC LETTERS
卷 10, 期 20, 页码 4605-4608出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol801868a
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资金
- National Institutes of Health [GM062820]
Fully protected 3,5-difluorotyrosine (F2Y), Fmoc-F2Y(tBu)-OH, is efficiently prepared by a chemoenzymatic process and incorporated into individual peptides and combinatorial peptide libraries. The F2Y-containing peptides display kinetic properties toward protein tyrosine phosphatases (PTPs) similar to their corresponding tyrosine-containing counterparts but are resistant to tyrosinase
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