期刊
ORGANIC LETTERS
卷 10, 期 17, 页码 3813-3816出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol801499s
关键词
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资金
- NIH [CA56304]
- Amgen
- Johnson & Johnson. Merck Co.,
- Novartis
- Pfizer
- GSK
- Bristol-Myers Squibb Pharmaceuticals
An enantioselective synthesis of (-)-kendomycin is described and is based on the application of the organosilane-based [4 + 2]-annulation strategy for the assembly of the C1a-C10 fragment. An underutilized samarium(II) iodide-assisted cyclization (intramolecular Barbier-type reaction) is employed to afford the protected macrocycle.
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