期刊
ORGANIC LETTERS
卷 10, 期 6, 页码 1151-1154出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol800058d
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资金
- NIDDK NIH HHS [DK-60532] Funding Source: Medline
A modular synthetic route to (indolyl)kojic acid anti-diabetes agents has been developed. Sonogashira coupling of a protected iodoaniline with a propargyl kojate was used to construct an (indole)methyl kojate. Its heteroaromatic Claisen rearrangement, followed by tautomerization to return the indole and pyrone rings, was used to create the biaryl C-C bond. This route should enable collections of insulin mimic drug candidates to be prepared from a few basic building blocks.
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