期刊
THROMBOSIS AND HAEMOSTASIS
卷 114, 期 3, 页码 490-497出版社
GEORG THIEME VERLAG KG
DOI: 10.1160/TH14-12-1068
关键词
Platelets; P2Y(12) inhibitors; antiplatelet medications; inflammation; infection
资金
- AstraZeneca
- Accumetrics
- Merck
- Aspen
- Thermo Fisher Scientific
- Medscape
- MRC [MR/L001594/1] Funding Source: UKRI
- Medical Research Council [MR/L001594/1] Funding Source: researchfish
Platelet P2Y(12) inhibitors form a major part of the treatment strategy for patients with acute coronary syndromes (ACS) due to the importance of the platelet P2Y(12) receptor in mediating the pathophysiology of arterial thrombosis. It has been increasingly recognised that platelets also have a critical role in inflammation and immune responses. P2Y(12) inhibitors reduce platelet release of pro-inflammatory a-granule contents and the formation of pro-inflammatory platelet-leukocyte aggregates. These are important mediators of inflammation in a variety of different contexts. Clinical evidence shows that P2Y(12) inhibition by clopidogrel is associated with a reduction in platelet-related mediators of inflammation, such as soluble P-selectin and CD40L, following atherothrombosis. Clopidogrel in addition to aspirin, compared to aspirin alone, also reduces markers of systemic inflammation such as tumour necrosis factor (TNF) alpha and C-reactive protein (CRP) following ACS. The more potent thienopyridine P2Y(12) inhibitor, prasugrel, has been shown to decrease platelet P-selectin expression and platelet-leukocyte aggregate formation compared to clopidogrel. The PLATO study suggested that the novel P2Y(12) inhibitor ticagrelor might improve clinical outcomes from pulmonary infections and sepsis compared to clopidogrel in patients with ACS. Ticagrelor is a more potent P2Y(12) inhibitor than clopidogrel and also inhibits cellular adenosine uptake via equilibrative nucleoside transporter (ENT) 1, whereas clopidogrel does not. Further examination of the involvement of these mechanisms in inflammation and immunity is therefore warranted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据