期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 41, 页码 7568-7573出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob02282h
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资金
- subsidy program for innovative business promotion of Shizuoka Prefecture, Japan SAN-Pro
- Japan Trust International Research Cooperation Project
- University of Shizuoka
C-Alkylation of N-alkylamides with styrenes is reported, proceeding in ambient air/moisture to give arylbutanamides and pharmaceutically-relevant scaffolds in excellent mass balance. Various amide and styrene derivatives were tolerated, rapidly affording molecular complexity in a single step; thus highlighting the future utility of this transformation in the synthetic chemistry toolbox. Reaction scalability (up to 65 g h(-1) product) was demonstrated using a Microwave Flow reactor, as the first example of a C-alkylation reaction using styrenes in continuous flow.
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