4.6 Article

Synthesis of 3-substituted quinolin-2(1H)-ones via the cyclization of o-alkynylisocyanobenzenes

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ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 38, 页码 7050-7054

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob01882k

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资金

  1. Thailand Research Fund, Mahidol University [IRN58W0005, BRG6180005]
  2. Center of Excellence for Innovation in Chemistry (PERCH-CIC)
  3. Office of the Higher Education Commission (Franco-Thai Cooperation Program in Higher Education and Research, PHC Siam 2017)
  4. Institute for the Promotion of Teaching Science and Technology and Science Achievement Scholarship of Thailand (SAST)

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A facile synthesis of various functionalized 3-substituted quinolin-2(1H)-ones through Ag(i) nitrate-catalyzed cyclization of o-alkynylisocyanobenzenes is described. The reaction allows rapid and convenient access to 3-substituted quinolin-2(1H)-one scaffolds in moderate to good yields.

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