期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 38, 页码 6961-6968出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob02007h
关键词
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资金
- University of Alicante
- Erasmus+programme
- European Commission
- EPSRC
- RS
- EPSRC [EP/M000028/1] Funding Source: UKRI
The preparation of chiral pool-derived nitrone 3 and its use in the protecting-group free, stereoselective synthesis of a range of 1,3-disubstituted tetrahydroisoquinolines is described. Grignard reagent additions to nitrone 3 yielded trans-1,3-disubstituted N-hydroxytetrahydroisoquinolines 6 with good levels of selectivity, while 1,3-dipolar cycloadditions to this nitrone provided access to 3-(2-hydroxyalkyl)isoquinolines 12 as single diastereomers.
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