期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 12, 期 31, 页码 5990-5994出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob01265h
关键词
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资金
- LabEx CSC Chemistry of Complex Systems
- European Community [CIG-2012-326112, IEF-2012-326113]
- French Embassy to Germany
- French MRT fellowship
- Region Alsace
The inability to decouple Lewis acid catalysis from undesirable Bronsted acid catalysed side reactions when water or other protic functional groups are necessarily present has forced chemists to choose between powerful but harsh catalysts or poor but mild ones, a dichotomy that restricts the substrate scope of dehydrative transformations such as the direct S(N)1 reaction of alcohols. A systematic survey of Lewis and Bronsted acids reveals that the strong non-hydrolyzable Lewis acid B(C6F5)(3) leads to highly chemoselective alcohol substitution in the presence of acid-sensitive alkenes, protecting groups and other functional groups without the typical compromise in reaction rates, substrate scope and catalyst loading.
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