期刊
THORAX
卷 71, 期 1, 页码 84-85出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2015-207449
关键词
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资金
- Medical Research Council [MR/K013351]
- National Institute of Aging (NIA) [R01AG034454]
- NordForsk
- Nordic Programme on Health and Welfare
- ESRC professorial fellowship [ES/J023299]
- British Heart Foundation [RG13/2/30098]
- Economic and Social Research Council (ESRC) studentship
- US NIH NIA [R01AG034454, R01AG013196]
- Department of Health and Social Security
- Tobacco Research Council
- NATIONAL INSTITUTE ON AGING [R01AG034454, R01AG013196] Funding Source: NIH RePORTER
- British Heart Foundation [RG/13/2/30098] Funding Source: researchfish
- Economic and Social Research Council [1223506, ES/J023299/1] Funding Source: researchfish
- Medical Research Council [MR/K013351/1, MR/K026992/1] Funding Source: researchfish
- ESRC [ES/J023299/1] Funding Source: UKRI
- MRC [MR/K013351/1] Funding Source: UKRI
Underweight adults have higher rates of respiratory death than the normal weight but it is unclear whether this association is causal or reflects illness-induced weight loss (reverse causality). Evidence from a 45-year follow-up of underweight participants for respiratory mortality in the Whitehall study (N=18 823; 2139 respiratory deaths) suggests that excess risk among the underweight is attributable to reverse causality. The age-adjusted and smoking-adjusted risk was 1.55-fold (95% CI 1.32 to 1.83) higher among underweight compared with normal weight participants, but attenuated in a stepwise manner to 1.14 (95% CI 0.76 to 1.71) after serial exclusions of deaths during the first 5-35 years of follow-up (P-trend<0.001).
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