期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 12, 期 44, 页码 8796-8802出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob01769b
关键词
-
资金
- University of Pittsburgh
- National Institutes of Health [R01GM107161]
A variety of non-biological structural motifs have been incorporated into the backbone of natural protein sequences. In parallel work, diverse unnatural oligomers of de novo design (termed foldamers) have been developed that fold in defined ways. In this Perspective article, we survey foundational studies on protein backbone engineering, with a focus on alterations made in the context of complex tertiary folds. We go on to summarize recent work illustrating the potential promise of these methods to provide a general framework for the construction of foldamer mimics of protein tertiary structures.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据