4.6 Article

Indole synthesis from N-allenyl-2-iodoanilines under mild conditions mediated by samarium(II) diiodide

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ORGANIC & BIOMOLECULAR CHEMISTRY
卷 12, 期 35, 页码 6812-6815

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob01164c

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  1. Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
  2. Kyoto Pharmaceutical University Fund for the Promotion of Scientific Research

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A novel method for indole skeleton synthesis under mild conditions mediated by samarium(II) diiodide has been developed. The reaction of N-allenyl-2-iodoaniline derivatives with SmI2 in the presence of HMPA and i-PrOH at 0 degrees C afforded indole derivatives in high yields.

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