期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 12, 期 47, 页码 9562-9571出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob01641f
关键词
-
资金
- Australian Cancer Research Foundation
- Australian Research Council
- ARC DECRA fellowship
- University of Newcastle
- Prime Minister's Australia Asia Postgraduate Award
Suzuki cross-couplings of 5-formyl-2-furanylboronic acid with activated or neutral aryl bromides were performed under continuous flow conditions in the presence of (Bu)(4)N+F- and the immobilised t-butyl based palladium catalyst CatCart (TM) FC1032 (TM). Deactivated aryl bromides and activated aryl chlorides were cross-coupled with 5-formyl-2-furanylboronic in the presence of (Bu)(4)N+OAc- using the bis-triphenylphosphine CatCart (TM) PdCl2(PPh3)(2)-DVB. Initial evidence indicates the latter method may serve as a universal approach to conduct Suzuki cross-couplings with the protocol successfully employed in the synthesis of the current gold standard Hedgehog pathway inhibitor LDE225.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据