Photoresponsive vesicle permeability based on intramolecular host-guest inclusion

This article describes light-responsive vesicles that can release their contents in response to a light-sensitive molecular trigger. To this end, liposomes were equipped with amphiphilic beta-cyclodextrin that was covalently labeled with azobenzene. Using dye encapsulation and confocal laser scanning microscopy, we show that the permeability of these vesicles strongly increases upon UV irradiation (lambda = 350 nm) with concomitant isomerization of apolar trans-azobenzene to polar cis-azobenzene on the Liposome surface.