期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 12, 期 9, 页码 1405-1411出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob42196a
关键词
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资金
- National Basic Research Program of China [2010CB833201]
- National Natural Science Foundation of China [21372013]
- Shenzhen Peacock Program [KQTD201103]
- Shenzhen innovation funds [GJHZ20120614144733420]
A general palladium catalyzed acetoxylation of benzylic C-H bonds has been developed. Picolinamides serve as an excellent directing group for the C-H activation of benzylic methyls. A wide range of 2-amino benzyl alcohol analogues were synthesized in good yields. The products demonstrated broad synthetic utilities toward various benzo-fused heterocycles. Mechanistic studies revealed the key rate-limiting C-H insertion step, which could be affected by the substitution pattern of the parent arene.
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