期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 11, 期 25, 页码 4147-4153出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob40489g
关键词
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资金
- BARDA [HHS0100200800062C]
- NIH/NIAID CMCR program [U19 AI068021-06]
- NIH/NIGMS CMLD program [P50 GM067082]
JP4-039 is a lead structure in a series of nitroxide conjugates that are capable of accumulating in mitochondria and scavenging reactive oxygen species (ROS). To explore structure-activity relationships (SAR), new analogs with variable nitroxide moieties were prepared. Furthermore, fluorophore-tagged analogs were synthesized and provided the opportunity for visualization in mitochondria. All analogs were tested for radioprotective and radiomitigative effects in 32Dcl3 cells.
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