4.6 Article

Catalytic, enantioselective 1,3-dipolar cycloadditions of nitrile imines with methyleneindolinones

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ORGANIC & BIOMOLECULAR CHEMISTRY
卷 11, 期 45, 页码 7834-7837

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob41815d

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  1. Iowa State University
  2. ISU Institute for Physical Research
  3. HHMI
  4. NIH [GM95697]
  5. Direct For Mathematical & Physical Scien
  6. Division Of Chemistry [1040098] Funding Source: National Science Foundation

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Catalytic, enantioselective 1,3-dipolar cycloadditions of nitrile imines with methyleneindolinones are reported. The spiro[pyrazolin-3,3'-oxindole] products are formed in good yields (up to 98%) and high enantioselectivity (up to 99% ee).

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