An asymmetric normal-electron-demand aza-Diels-Alder reaction via trienamine catalysis

An asymmetric normal-electron-demand aza-Diels-Alder cyclo-addition of 2-aryl-3H-indol-3-ones and 2,4-dienals was explored via trienamine catalysis of a chiral secondary amine. Multifunctional tricyclic polyhydropyrido[1,2-a]indoles were efficiently constructed in good stereoselectivity (up to 92% ee, >19: 1 dr).