4.6 Article

Organocatalytic functionalization of heteroaromatic N-oxides with C-nucleophiles using in situ generated onium amide bases

期刊

ORGANIC & BIOMOLECULAR CHEMISTRY
卷 11, 期 27, 页码 4438-4441

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob40782a

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资金

  1. Japan Society for the Promotion of Science [23390002, 23659001, 23790002]
  2. Ministry of Education, Culture, Sports, Science and Technology, Japan [23390002]
  3. Grants-in-Aid for Scientific Research [23390002, 25670002, 25460002, 23659001] Funding Source: KAKEN

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Organocatalytic functionalization of heteroaromatic N-oxides was investigated using in situ generated onium amide bases, and C-nucleophiles were efficiently introduced by the sequential addition-elimination reaction under metal-free conditions, affording 2-substituted nitrogen heteroaromatics generally in good to high yields.

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