期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 11, 期 17, 页码 2903-2910出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob27385g
关键词
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资金
- Israel Science Foundation (ISF)
- German-Israeli Foundation (GIF)
- German Federal Ministry of Education and Research
Bacteria will gain an advantage if they are able to metabolize nutrients that are inaccessible for other bacteria. To demonstrate this principle, we developed a simple model system, which mimics how bacteria exploit natural carbon sources. A masked glucose precursor that is activated by beta-galactosidase was used as a carbon source for bacterial growth in a glucose-deficient medium. No bacterial growth was observed in the presence of control substances in which beta-galactosidase mediated cleavage did not lead to glucose release. This study represents a proof-of-principle example in which a bacterium can grow in a nutrient-free medium by inducible, enzyme-mediated nutrient release from a precursor.
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