期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 11, 期 17, 页码 2787-2803出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob40222c
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资金
- Deutsche Forschungsgemeinschaft [SCHN 441/9-1]
- Alexander von Humboldt Foundation
The titanium-BINOLate-catalyzed, highly enantioselective ring-opening reaction of meso-aziridines has been developed which furnishes trans-1,2-diamines in typically good yields and excellent enantioselectivities. N-Aryl aziridines attached to a 5- or 6-membered carbocyclic ring are among the best substrates for this process providing the products in up to >99% ee. The chiral catalyst is easily prepared in situ from commercially available components and does not require any laborious ligand synthesis. Structural investigations into the catalyst composition reveal an oligomeric structure of the active Ti-complex.
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