期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 10, 期 19, 页码 3946-3954出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob25227a
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资金
- Region Haute-Normandie
- CRUNCH network (Centre de Recherche Universitaire Normand de Chimie)
- Ministere de la Recherche
- CNRS (Centre National de la Recherche Scientifique)
The straightforward asymmetric construction of bio-relevant. Delta(2)-pyrazolines having either N-(thio)amide or N-acetyl functional groups and flanked by aryl substituents such as phenol at C3 and C5 has been achieved through an enantioselective phase transfer organocatalytic addition of N-Boc hydrazine to chalcones followed by a transprotection sequence allowing N-Boc transformation into N-CXNHR (X = S, O) or N-Ac functional groups. This approach was applied to a straightforward elaboration of chiral monoamine oxidase inhibitor derivatives.
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