期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 10, 期 6, 页码 1137-1144出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob06394d
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The synthesis of naturally occurring glycosylated (2S,5R)-hydroxylysine still remains a challenge. This perspective highlights the importance of this post-translationally modified amino acid residue in the observed bioactivity of collagen and related collagen-like proteins such as adiponectin, an important target for the treatment of type II diabetes. Strategies employed to date for the syntheses of (2S,5R)-hydroxylysine and the methods to effect glycosylation of this modified amino acid are also summarized herein.
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