Direct, nucleophilic radiosynthesis of [F-18]trifluoroalkyl tosylates: improved labelling procedures

A rapid and efficient protocol to afford the title compound 2-[F-18]-fluoro-2,2-difluoroethyl tosylate ([F-18]7b) is described. Starting from [F-18]fluoride ion, labelling reagent 7b was obtained in good yields and a high specific radioactivity. Compound ([F-18]7b) was then used to synthesise a prospective radiotracer for PET-imaging in dementia.