期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 10, 期 30, 页码 6087-6093出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob25119a
关键词
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资金
- University of Geneva
- European Research Council (ERC)
- National Centre of Competence in Research (NCCR) Chemical Biology
- Swiss NSF
Dynamic amphiphiles provide access to transmembrane ion transport, differential sensing and cellular uptake. In this report, we introduce dynamic amphiphiles with fluorescent tails. Core-substituted naphthalenediimides (cNDIs) and perylenediimides (cPDIs) are tested. Whereas the latter suffer from poor partitioning, dynamic cNDI amphiphiles are found to be purifiable by RP-HPLC, to partition selectively into liquid-disordered (Ld) microdomains of mixed lipid bilayers and to activate DNA as transporters. Importantly, fluorescence properties, partitioning and activity can be modulated by changes in the structure of mixed amphiphiles. These results confirm the potential of dynamic fluorescent amphiphiles to selectively label extra-and intracellular membrane domains and visualize biological function.
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