4.6 Article

Copper(II)-mediated oxidative cyclization of enamides to oxazoles

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ORGANIC & BIOMOLECULAR CHEMISTRY
卷 10, 期 19, 页码 3866-3870

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob25310k

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  1. U.S. Department of Energy [DE-FG02-05ER15690]
  2. NSF [CHE-9208463, CHE-0342998, CHE-9629688, CHE-9974839]

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The copper(II)-mediated oxidative cyclization of enamides to oxazoles is reported. A range of 2,5-disubstituted oxazoles were prepared in moderate to good yields in two steps from simple amide and alkyne precursors.

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