期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 10, 期 12, 页码 2380-2384出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob07084g
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资金
- CSIR [01(2490)/11/EMR-II]
- DST, New Delhi, India [SR/S1/IC-35/2006]
- UGC (UGC-NET)
A highly selective and sensitive fluorescent Zn2+ sensor, 2,6-bis(2-hydroxy-benzoic acid hydrazide)-4-methylphenol (1), was designed and synthesized. In aqueous THF (4 : 6 v/v) ligand 1 induces a 2 : 1 complex formation with respect to Zn2+ at physiological pH. This probe features visible light excitation(390 nm) and emission (490 nm) profiles, excellent selectivity responses for Zn2+ over other competing biological metal ions with K-d < 1 pM(2), LOD < 1 ng L-1 and about 680 fold enhancement in fluorescent intensity upon Zn2+ binding. It also exhibits cell permeability and intracellular Zn2+ sensing in A375 human melanoma cancer cell.
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