期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 10, 期 1, 页码 122-125出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob06088k
关键词
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资金
- National Institutes of Health [GM065966, T32 GM070421]
- Defense Threat Reduction Agency [BRBAA08-L-2-0001]
During in vitro selection for DNA-catalyzed lysine reactivity, we identified a deoxyribozyme that instead catalyzes nucleophilic attack of a phosphoramidate functional group at a 5'-triphosphate-RNA, forming an unusual pyrophosphoramidate (N-P-V-O-P-V) linkage. This finding highlights the relatively poor nucleophilicity of nitrogen using nucleic acid catalysts, indicating a major challenge for future experimental investigation.
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