期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 10, 期 48, 页码 9671-9676出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26988k
关键词
-
资金
- IMB Postgraduate Award
- University of Queensland International Postgraduate Scholarship
- Institute for Molecular Bioscience, The University of Queensland
- Australian Research Council [ARC LP0775547, LP0989954]
- Noscira (Madrid, Spain)
- Australian Research Council [LP0989954] Funding Source: Australian Research Council
An intertidal sample of the Australian marine brown alga, Zonaria spiralis, exhibited promising kinase inhibitory and antibacterial activity. Chemical analysis returned six phloroglucinol-derived lipids, the new hemiketal spiralisones A-D (1-4) and the known chromones 5-6, and the known norsesquiterpenoid apo-9'-fucoxanthinone (7). Structures 1-7 were assigned on the basis of detailed spectroscopic analysis, biosynthetic considerations and total synthesis. Spiralisones undergo facile acid-mediated dehydration to yield the corresponding chromones, revealing for the first time that brown algal chromones may be handling artifacts rather than natural products. Hemiketals 1 and 2, and chromone 6, displayed inhibitory activity against the neurodegenerative disease kinase targets CDK5/p25, CK1 delta and GSK3 beta, while hemiketals 1, 3 and 4, and chromone 6, displayed growth inhibitory activity against the Gram-positive bacteria Bacillus subtilis (ATCC 6051 and 6633). The promising kinase inhibitory and antibacterial properties of the Z. spiralis extract were attributed to the cumulative effect of many moderately potent phloroglucinol-derived lipid co-metabolites.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据