期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 10, 期 1, 页码 181-194出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob06554h
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资金
- Netherlands Organisation for Scientific Research (NWO)
- Netherlands Genomics Initiative (NGI), U.S. National Cancer Institute [5RO1CA124634]
Syringolins, a class of natural products, potently and selectively inhibit the proteasome and show promising antitumour activity. To gain insight in the mode of action of syringolins, the ureido structural element present in syringolins is incorporated in oligopeptide vinyl sulfones and peptide epoxyketones yielding a focused library of potent new proteasome inhibitors. The distance of the ureido linkage with respect to the electrophilic trap strongly influences subunit selectivity within the proteasome. Compounds 13 and 15 are beta 5 selective and their potency exceeds that of syringolin A. In contrast, 5 may well be the most potent beta 1 selective compound active in living cells reported to date.
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