期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 10, 期 24, 页码 4685-4688出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob25625h
关键词
-
资金
- EPSRC
- AstraZeneca
The first synthesis of hydroxy-iso-evoninic acid (2), a pyridyl diacid found as a macrodilactone bridging ligand in bioactive Celastraceae sesquiterpenoid-based natural products, has been achieved in 9 steps and an overall yield of 26%. The synthesis utilizes a benzilic ester rearrangement (BER) and a late stage benzylic oxidation to give access to all four stereoisomers whose absolute stereochemistry was assigned following chromatographic separation and anomalous dispersion X-ray crystallography.
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