期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 10, 期 34, 页码 6945-6950出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob25874a
关键词
-
资金
- European Union [LSHC-CT-2005-518417 'Epitron']
- Ministerio de Economia y Competitividad-Spain [SAF2010-17935-FEDER]
- Xunta de Galicia from DXI+D+i [08CSA052383PR]
- Xunta de Galicia from DXPCTSUG [2006/15]
- Xunta de Galicia (Inbiomed)
The synthesis of dioxepine bastadin 3, a tyrosine-tyramine derivative with a dibenzo-1,3-dioxepine scaffold that is rarely present among natural products, is described. The dibenzo-1,3-dioxepine ring was formed early in the sequence and the (E)-2-(hydroxyimino)-N-alkylamide was generated in the last step by oxidation of the 2-amino-N-alkylamide precursor. The presumably biogenetic late-stage ring formation starting from congener bastadin 3 failed. A new synthesis of this alkaloid was also developed. This new route requires a minimal use of protecting groups and the order of the two key steps was reversed relative to the route to dioxepine bastadin 3.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据