Enantio- and periselective nitroalkene Diels-Alder reaction

The periselective Diels-Alder reaction of 5-substituted penta-methylcyclopentadienes and nitroethylene has been realized by helical-chiral hydrogen bond donor catalysts. To our knowledge, this represents the first asymmetric catalytic nitroalkene Diels-Alder reaction via activation of nitroalkene, and thus establishes its proof-of-principle.