A highly active catalytic system for Suzuki-Miyaura cross-coupling reactions of aryl and heteroaryl chlorides in water

An easily available Pd(OAc)(2)/(2-mesitylindenyl)dicyclohexylphosphine/Me(octyl)(3)N+Cl-/K3PO4 center dot 3H(2)O catalytic system was developed and it shows high catalytic activity in the Suzuki-Miyaura cross-coupling reaction of a diverse array of aryl and heteroaryl chlorides in water. Notably, this catalytic system also works with ultra-low loading of the catalyst with high turnover numbers.