期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 20, 页码 7168-7175出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05856h
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资金
- Spanish Government [CTQ2009-11027/BQU]
- Fondecyt [1100278]
- Fondecyt through the Cooperacion Internacional
The nucleophilicity N index (J. Org. Chem. 2008, 73, 4615), the inverse of the electrophilicity, 1/omega, and the recently proposed inverse of the electrodonating power, 1/omega(-), (J. Org. Chem. 2010, 75, 4957) have been checked toward (i) a series of single 5-substituted indoles for which rate constants are available, (ii) a series of para-substituted phenols, and for (iii) a series of 2,5-disubstituted bicyclic[2.2.1]hepta-2,5-dienes which display concurrently electrophilic and nucleophilic behaviors. While all considered indices account well for the nucleophilic behavior of organic molecules having a single substitution, the nucleophilicity N index works better for more complex molecules. Unlike, the inverse of the electrophilicity, 1/omega, (R-2 = 0.71), and the inverse of the electrodonating power, 1/omega(-) (R-2 = 0.83), a very good correlation of the nucleophilicity N index of twelve 2-substituted-6-methoxy-bicyclic[2.2.1]hepta-2,5-dienes versus the activation energy associated with the nucleophilic attack on 1,1-dicyanoethylene is found (R-2 = 0.99). This comparative study allows to assert that the nucleophilicity N index is a measure of the nucleophilicity of complex organic molecules displaying concurrently electrophilic and nucleophilic behaviors.
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