期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 13, 页码 4921-4926出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob01188f
关键词
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A conjugation of bile acids with peptides via Cu(I)-catalyzed click chemistry has been described. Novel bile acid-peptide conjugates linked via a 1,2,3-triazole moiety based on cholic, deoxycholic and lithocholic acid derivatives were synthesized using Cu(I)-catalyzed 1,3-dipolar cycloaddition (click reaction). It was shown that up to three peptide fragments can be attached to a central steroid core, thus forming complex three-dimensional polyconjugate structures, which can find important applications in biochemistry, medicinal chemistry, and coordination chemistry.
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