期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 8, 页码 2685-2701出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00657b
关键词
-
资金
- Robert A. Welch Foundation [Y-1362, Y-1289]
- National Institutes of Health [GM065503]
- NSF [CHE-0234811, CHE-9601771]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM065503] Funding Source: NIH RePORTER
An investigation of 4-vinylimidazoles as diene components in the intramolecular Diels-Alder reaction is described. In the course of these studies several parameters affecting the cycloaddition were evaluated including the nature of the imidazole protecting group, the type of dienophile and the linking group. These investigations established that amino linkers were generally more effective than either ethers or esters. In most cases, the cycloadditions were highly stereoselective, resulting in the formation of products derived from an anti transition state. The polysubstituted tetrahydrobenzimidazole core of the pyrrole-imidazole alkaloid ageliferin can be constructed through the use of pseudo dimeric 4-vinylimidazoles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据