期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 22, 页码 7860-7868出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05965c
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- Aesica
- University of Sheffield
A highly active organocatalyst has been shown to affect the asymmetric reductive amination of ketones producing both aromatic and aliphatic amines. At 1 mol% catalyst loading, a series of structurally diverse chiral amines were quickly and economically prepared with good enantioselectivity and generally useful yield. The efficient synthesis of the calcimimetic (+)-NPS R-568 (67%, 89% ee) demonstrated the synthetic applicability of this methodology.
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