期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 19, 页码 6519-6523出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05753g
关键词
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资金
- Spanish Ministry of Science and Innovation (MICINN) [AYA2009-13920-C02-02]
- University of Bologna
- ICREA Funding Source: Custom
An efficient synthesis of spiropyrazolones based on organocatalysis is described. The reaction between pyrazolones, enolizable aldehydes and enals is catalyzed by secondary amine catalysts and affords the final spiro compounds bearing four contiguous chiral centers in good yields and excellent diastereo- and enantioselectivities.
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