期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 19, 页码 6575-6578出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05808h
关键词
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资金
- National Science Foundation [CHE-0847262]
- Direct For Mathematical & Physical Scien [0847262] Funding Source: National Science Foundation
A prototype tube-in-tube reactor in which it is possible to load gas and heat simultaneously has been used in a continuous-flow approach to alkoxycarbonylation reactions of aryl iodides. In the stainless steel coil, liquid flows on the outside of a gas-permeable membrane. The coil can be heated and the temperature can be measured accurately via a probe touching the outer steel surface. A range of aryl iodides can be transformed to the corresponding esters in excellent conversion by reaction at 120 degrees C using 0.5 mol% palladium acetate as the catalyst with no additional ligand required. Small-scale optimization and substrate screening runs were followed by scale-up.
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