期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 15, 页码 5476-5481出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05605k
关键词
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资金
- National Institute of Health [GM055769]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM055769] Funding Source: NIH RePORTER
Anti-biofilm agents have been developed based upon the flustramine family of alkaloids isolated from Flustra foliacea. A Garg interrupted Fischer indolization reaction was employed to access a core pyrroloindoline scaffold that was subsequently employed to create a pyrroloindoline triazole amide library. Screening for the ability to modulate biofilm formation against strains of Gram-positive and Gram-negative bacteria identified several compounds with low micromolar, non-toxic IC50 values.
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