期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 5, 页码 1381-1388出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00438c
关键词
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资金
- Danish Research Agency
- Nucleic Acid Center
- Danish National Research Foundation
- NAC-DRUG (Nucleic Acid Based Drug Design Training Center) [MEST-CT-2004-504018]
- Danish Natural Science Research Council
- Mollerens Fond
Four double-headed nucleosides were prepared by the CuAAC reaction. Hereby, a triazole-containing linker connects an additional thymine or adenine to the 2'-position of 2'-deoxyuridine, a thymine to the 5'-position of thymidine and a thymine to the 6'-position of an LNA-thymidine monomer. Whereas no conclusive recognition effects of the additional thymines were found when introduced in LNA or at the 5'-position, both thymine and adenine in the 2'-position were found to stabilise three-way junctions in both dsDNA and DNA: RNA contexts and to give cross-strand interactions in a DNA-duplex, when specifically introduced in a so-called (+1)-zipper motif.
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