期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 5, 页码 1347-1351出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob01050b
关键词
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资金
- National Institutes of Health [CA126937, CA152194]
- CNPq
- CAPES
- FAPESP
- NATIONAL CANCER INSTITUTE [R01CA126937, R01CA152194] Funding Source: NIH RePORTER
A series of organochalcogenanes was synthesized and evaluated as protein tyrosine phosphatases (PTPs) inhibitors. The results indicate that organochalcogenanes inactivate the PTPs in a time- and concentration-dependent fashion, most likely through covalent modification of the active site sulfur-moiety by the chalcogen atom. Consequently, organochalcogenanes represent a new class of mechanism-based probes to modulate the PTP-mediated cellular processes.
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