期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 1, 页码 297-306出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00529k
关键词
-
资金
- EPSRC
- University of Nottingham
- Rhone-Poulenc Agriculture
N-Alkylation of optically active 1-benzyl-4-phenyl-4,5-dihydroimidazole with active alkyl halides and treatment of the so-formed 4,5-dihydroimidazolium ions with DBU in the presence of a range of electron-deficient alkene dipolarophiles, constitutes a 'one-pot' cascade terminating in a 1,3-dipolar cycloaddition reaction that affords optically active pyrrolo[1,2-a]imidazoles. Three bonds of the so-formed pyrrolidine moiety are constructed in this cascade. The cycloaddition follows an endo approach of dipole and dipolarophile with anti geometry of the dipole and facial selectivity derived from the phenyl substituent. Inter-and intramolecular cycloaddition modes are observed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据