期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 19, 页码 6513-6518出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05874f
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资金
- The National Institutes of Health [GM087981]
- The Robert A. Welch Foundation [A-1121]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM087981] Funding Source: NIH RePORTER
Two cationic polyfluorene derivatives, quaternary amine 1 and guanidine 2 sheathed systems, were prepared as potential carriers to mediate import of proteins into cells without requiring covalent attachment to the protein. Neither polymer showed significant cytotoxicities (IC50 100 mu M) when exposed to Clone 9 rat liver cells. Both polymers were shown to mediate import of a series of four proteins chosen because they have different pI values, sizes, and variable organic fluor attachments. Once inside the cells, the quaternary amine system 1 released more of its cargo into regions outside the lysosomes. In one exploratory experiment, pyrenebutyrate was shown to accelerate import of a protein system by polymer 1.
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